Side effect of metformin hcl 500 mg9/17/2023 ![]() ![]() The biologically inert components of the tablet may occasionally remain intact during GI transit and will be eliminated in the feces as a soft, hydrated mass. The hydrated polymer system is not rigid and is expected to be broken up by normal peristalsis in the GI tract. Drug is released slowly from the dosage form by a process of diffusion through the gel matrix that is essentially independent of pH. After administration, fluid from the gastrointestinal (GI) tract enters the tablet, causing the polymers to hydrate and swell. Metformin hydrochloride is combined with a drug release controlling polymers to form a monophasic matrix system. System Components and Performance-Metformin hydrochloride extended - release tablets comprises a hydrophilic polymer matrix system. Metformin hydrochloride extended - release tablets meet USP dissolution test 10. ![]() Metformin hydrochloride extended - release tablets 750 mg contain the inactive ingredients xanthan gum, hypromellose, sodium carbonate, povidone, talc, colloidal silicon dioxide, magnesium stearate and ferric oxide (red). Metformin hydrochloride extended - release tablets 500 mg contain the inactive ingredients xanthan gum, hypromellose, sodium carbonate, povidone, talc, colloidal silicon dioxide and magnesium stearate. Metformin hydrochloride extended - release tablets, USP contain 500 mg or 750 mg of metformin hydrochloride USP as the active ingredient. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. Metformin hydrochloride is a white to off-white crystalline compound with a molecular formula of C4H11N5 Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride) is not chemically or pharmacologically related to any other classes of oral antihyperglycemic agents. Metformin hydrochloride extended - release tablets are oral antihyperglycemic drugs used in the management of type 2 diabetes. ![]()
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